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The Tennessee Junior Science and Humanities Symposium is administered by the University of Tennessee, Knoxville and is based in the Office of Undergraduate Admissions. In addition to the Office of Undergraduate Admissions, judges are provided by the University of Tennessee, Knoxville College of Arts and Sciences, Institute of Agriculture, Tickle College of Engineering, and UT-Battelle, the management contractor of the Oak Ridge National Laboratory on behalf of the US Department of Energy. Additional programming partners include the Oak Ridge National Laboratory, the U.S. Naval Research Laboratory, and the Tennessee Department of Health.

The TJSHS sponsors the attendance and participation of selected statewide high school science students (grades 9–12). The funding covers food, lodging, and event space for students and their teacher mentors for the entirety of the event. Basic funding for the TJSHS is provided by a grant from the National Science Teaching Association with supplementary funding provided by supporting sponsors.